• br Summary and conclusions br

  2018-10-20

  

  Summary and conclusions Introduction Historically, the foundations of the concept that the heart is a static organ incapable of regeneration were established in the mid-1920s. A significant publication in 1925 claimed that mitotic figures are not detectable in human cardiomyocytes (Karsner et

• In the present study we tested five

  2018-10-20

  

  In the present study, we tested five different pharmacological agents that are commonly used as selective inhibitors of Nodal/Activin signaling, namely SB431542, LY364947, A-83-01, SB505124, and SB525334 (Inman et al., 2002; Callahan et al., 2002; Laping et al., 2002; DaCosta Byfield et al., 2004; L

• In our prior studies we

  2018-10-20

  

  In our prior studies, we showed that K-RasG12D promotes proliferation in the intestinal epithelium by activating MEK, but that K-RasG12D promotes proliferation of colorectal cancer SB 203580 hydrochloride through a MEK-independent mechanism (Haigis et al., 2008). To determine whether K-RasG12D prom

• Our coculture experiments demonstrated that all three

  2018-10-20

  

  Our coculture experiments demonstrated that all three MSCs showed a similar low in vitro proliferation; for most patients coculture of all three MSCs with primary human AML g to mol calculator did not alter MSC proliferation but a minor increase in the proliferation was seen for a minority of patie

• Based on the differentiation and siRNA

  2018-10-20

  

  Based on the differentiation and siRNA studies reported here, the mechanistic regulation of FOXM1 towards pluripotency control and differentiation might differ between mouse and human ES cells. The discrepancy can be attributed to the different developmental status of human versus mouse ES cells (Ni

• raf inhibitors Here we demonstrate that the

  2018-10-20

  

  Here, we demonstrate that the methylation patterns of the H19/IGF2 and SNRPN DMRs were stable from the early stages of derivation to late passages of monkey ESCs, and following in vitro differentiation. We also showed that the H19/IGF2 DMR methylation pattern was correlated with the capacity of earl

• Sca has for a number of years been

  2018-10-20

  

  Sca-1 has for a number of years been used as a positive marker to isolate stem cells or progenitor cells from a number of tissues (Spangrude et al., 1988; Klimmeck et al., 2014; Holmes and Stanford, 2007). Inclusion of mCAP against Sca-1 in the antibody panels is now more or less standard when FACS

• Cell adhesion molecules CAMs are transmembrane proteins that

  2018-10-20

  

  Cell adhesion molecules (CAMs) are transmembrane proteins that are responsible for mediating adhesion of cells to other cells and/or the extracellular matrix via their extracellular domains, while their intracellular domain interacts with the cytoskeleton. Thus, CAMs provide a direct link between th

• In summary using the Nurr agonist AQ we first showed

  2018-10-20

  

  In summary, using the Nurr1 agonist AQ we first showed that Nurr1 plays an important role in the regulation of adult hippocampal neurogenesis. AQ may increase adult hippocampal neurogenesis via, in part, an up-regulated phosphorylation of Akt and ERK1/2. Moreover, the Nurr1 agonist enhances both sho

• br Material methods br Results br Discussion br

  2018-10-20

  

  Material & methods Results Discussion Acknowledgements We thank Melissa Carballosa-Gautam in the Miami Project to Cure Paralysis Imaging Core. This design, experimentation, data analysis and manuscript writing was supported by the Miami Project to Cure Paralysis; NIH/NINDS (DJL: NS049545

• Our studies show that only a subpopulation of hESCs

  2018-10-20

  

  Our studies show that only a subpopulation of hESCs at the top of the hierarchy possesses an extensive capacity for self-renewal. Polanco et al. recently showed that glutathione s-transferase in this compartment could reestablish the continuum of cell states seen in unfractionated cultures (Polanco

• Cell transplantation therapy is a promising approach to prom

  2018-10-20

  

  Cell transplantation therapy is a promising approach to promote remyelination in MS patients; human embryonic stem salubrinal (hESCs) and induced pluripotent stem cells, as well as fetal brain, are potential sources of therapeutic cells (Brüstle et al., 1999; Müller et al., 2006). Studies in animal

• We have demonstrated that donor specific DNAm patterns are

  2018-10-20

  

  We have demonstrated that donor-specific DNAm patterns are maintained upon reprogramming into iPSCs (Shao et al., 2013), and these also remain upon redifferentiation into iPS-MSCs. Thus, there is some epigenetic memory after chromatin remodeling—whether these donor-specific DNAm patterns are functio

• br Results We investigated the identity

  2018-10-20

  

  Results We investigated the identity of human NPCs extracted from the foreskin dermis through fluorescence-activated cell sorting (FACS)-based isolation of cell subpopulations and subsequent characterization of the sorted chemokine receptor (Figure 1). Immunofluorescent and flow-cytometry analys

• Based on their well documented activity

  2018-10-20

  

  Based on their well-documented activity profile, we employed M-CSF and G-CSF to direct terminal myeloid differentiation toward the monocyte/macrophage or granulocyte lineage in our studies. We found that the IL-3/M-CSF combination efficiently promoted the differentiation of iPSCs into iPSC-MΦ that r

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