• The present study manipulated dopaminergic functioning by

  2021-06-23

  

  The present study “manipulated” dopaminergic functioning by examining genetic variation related to the catechol-O-methyltransferase (COMT) gene. The gene transcribes the COMT enzyme involved in degradation of released dopamine in the frontal cortex. COMT is primarily localized to the frontal cortex

• COMT expression protein level and activity are

  2021-06-23

  

  COMT expression, protein level and activity are down regulated by E2. Using estrogen receptor (ER) positive MCF-7 cells, Xie et al. demonstrated an E2 dose dependent (1, 10 and 100 nM) decrease in S-COMT 1.3 kb mRNA that was maximum after 48 h (Xie et al., 1999). A similar decrease was not observed

• A similar pattern was observed for

  2021-06-23

  

  A similar pattern was observed for both tissues of P. harpagos, evidencing the absolute predominance of acetylcholinesterase. As observed, no effects were attributed to Iso-OMPA. The hypothesis that the major cholinesterasic form is AChE was reinforced considering the higher hydrolytic activity, whi

• CCT241533 It is of interest to point out that curcumin in

  2021-06-23

  

  It is of interest to point out that curcumin in this study reduced body weight gain; the underlying mechanism may be due to a decrease in general CCT241533 of fat, which was associated with a significantly reduced NPC1L1 expression in small intestine. Labonte et al revealed that NPC1L1 deficiency or

• Data from immunohistochemical detection of CIC revealed that

  2021-06-23

  

  Data from immunohistochemical detection of CIC-3 revealed that the immunostaining of CIC-3 can be present both in hepatocarcinoma and its matched normal controls though; CIC-3 was, on the whole, significantly elevated in hepatocarcinoma relative to its paired normal control. In consideration of the

• Abbas et al studied the mitigation of ASR in

  2021-06-23

  

  Abbas et al. studied the mitigation of ASR in their corresponding study by incorporating RHA [1]. These researchers used Ordinary Portland Cement (OPC), four different percentages (i.e., 10%, 20%, 30% and 40% by weight of OPC) of RHA and reactive aggregate (sand from Dolomite-limestone rock) in thei

• Fujimoto et al pointed out that RPN knockout

  2021-06-23

  

  Fujimoto et al. pointed out that RPN2 knockout alleviated the resistance of GC pak4 (MKN74 and KATO III) to docetaxel and DDP [23]. Yuan et al. demonstrated that the depletion of RPN2 resulted in the reduction in resistance of GC cells to drugs such as irinotecan, docetaxel, doxorubicin, oxaliplati

• Additionally in the presented study both

  2021-06-23

  

  Additionally, in the presented study both the NSE values and MFI levels of the CD45−CD34 + CXCR7+ g 36 receptor correlated positively with the inflammatory parameter – CRP. CXCR7 expression has been found to be enhanced during pathological processes such as inflammation and neoplasms (Janssens et al

• br Introduction Rheumatoid arthritis RA is a chronic systemi

  2021-06-23

  

  Introduction Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease that can be divided in at least two subsets based on the presence of antibodies to citrullinated proteins (ACPAs) [1]. Importantly, such ACPA target proteins [[2], [3], [4], [5]] also represent candidate autoantige

• PKA signalling in the nucleus was thought to be

  2021-06-23

  

  PKA signalling in the nucleus was thought to be due to the translocation of the catalytic subunit upon activation from the SCH 727965 to the nucleus via diffusion [72]. However, a new understanding has emerged, as both the regulatory and catalytic subunits have been identified in the nucleus and fu

• Enzymatic assay The usual in vitro test for the

  2021-06-22

  

  Enzymatic assay. The usual in vitro test for the measure of the activity of DbH involves ascorbate as a cosubstrate (e.g., 5mM) and tyramine as a substrate (e.g., 10mM). When using N-aryl-N′-hydroxyguanidines instead of ascorbate, the hydroxylase activity of DbH was measured by HPLC as the amounts o

• In the present study DRD decreased in the VTA of

  2021-06-22

  

  In the present study, DRD3 decreased in the VTA of OA when compared with the control group. It is reported that DRD3 in the VTA control the firing rate of dopaminergic neurons and inhibition of these receptors enhance firing in the VTA-projecting neurons [18]. A study also indicated that morphine tr

• Acknowledgments We acknowledge the Danish Council for Indepe

  2021-06-22

  

  Acknowledgments We acknowledge the Danish Council for Independent Research (Grant no. 11-105250) and the Carlsberg Foundation (Grant no. 2011-01-0567) for funding this work. Introduction DNA is vital as a biological target to design diagnostic agents as well as therapeutic drugs. The recognitio

• In the gel shown in Figure

  2021-06-22

  

  In the gel shown in Figure 8, at early time-points, 14% of the input dsDNA is converted to these intermediate species. These persist in the gel to later times, with approximately 50% of these being unwound. This unwinding occurs at a considerably slower rate and is due to that fraction of the popula

• DAPK is a kD Ca calmodulin CaM regulated Ser

  2021-06-22

  

  DAPK is a 160-kD Ca2+/calmodulin (CaM)-regulated Ser/Thr kinase that mediates cell death. The activated forms of DAPK and DRP-1 are capable of inducing two distinct cytoplasmic events characteristic of programmed cell death, including membrane blebbing and the formation of autophagic vesicles (Inbal

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