• br Introduction Connexins are transmembrane proteins that al

  2022-05-04

  

  Introduction Connexins are transmembrane proteins that allow the exchange of molecules with the extracellular environment or adjacent BMS265246 via channels in the plasma membrane. Intercellular communication and exchange of biologically active molecules, salts, and nutrients to the extracellula

• br STAR Methods br Introduction Secretase is a membrane embe

  2022-05-04

  

  STAR★Methods Introduction γ-Secretase is a membrane-embedded proteolytic complex belonging to a diverse family of intramembrane-cleaving proteases and is composed of four integral membrane proteins: presenilin (PS), nicastrin (NCT), anterior pharynx-defective 1 (Aph-1), and presenilin enhancer

• br Site of expression FASTK is

  2022-04-29

  

  Site of expression FASTK is expressed in various parts of human body including heart, skeletal muscle, brain, placenta, lung, liver, kidney pancreas (Ota et al., 2004) and many other organs (Fig. 1). It has been reported that FASTK is highly expressed in pancreatic tumors, where it is involved in

• br Acknowledgements Funding for this study is gratefully ack

  2022-04-29

  

  Acknowledgements Funding for this study is gratefully acknowledged from the Department of Employment and Learning (QC) and the Northern Ireland Chest Heart and Stroke Association (2008107). Introduction Preeclampsia is a major human pregnancy-specific disorder that occurs in at least 5–10% of

• Sirolimus rapamycin and everolimus both

  2022-04-29

  

  Sirolimus (rapamycin) and everolimus, both of which are mTOR inhibitors, are released by commonly used first- and second-generation DES. Considering the relatively high rates of the target vessel failure with currently available DES [12,14,16,45,46], there is a need for a novel drug strategy that pr

• There has been conflicting evidence on

  2022-04-29

  

  There has been conflicting evidence on the possible receptor mechanisms that mediate the neuro-immuno-modulatory effects of FAAH substrates. Evidence from in vitro studies indicates that AEA-mediated modulation of TLR4-induced neuroinflammation may be mediated by CB1/CB2 receptor dependent (Correa e

• br Experimental br Acknowledgments We thank Mintek

  2022-04-29

  

  Experimental Acknowledgments We thank Mintek and Rhodes University for generous financial support and permission to publish these findings. T.O.O. gratefully acknowledges Obafemi Awolowo University, Ile-Ife, Nigeria for study leave. Introduction There are ∼35.3 million people living with H

• In the Joint United Nations Program on HIV AIDS

  2022-04-29

  

  In 2015, the Joint United Nations Program on HIV/AIDS (UNAIDS) proposed that by 2020, 90% of people living with HIV should be aware of their HIV status, as the first part of 90-90-90 strategy to end AIDS epidemic. Early detection of HIV allows initiating care for proper treatment, which impacts in m

• br Mammalian chromosomal DNA binds to various proteins and t

  2022-04-29

  

  Mammalian chromosomal DNA binds to various proteins and the DNA-protein complexes form DNA packaging units, called nucleosomes. Histones are the chief protein components of nucleosomes and perform pivotal functions in chromosomal gene regulation. Moreover, many types of chemical modifications of h

• Although we showed that RBL H Sc

  2022-04-29

  

  Although we showed that RBL-2H3 Sc98 LB-100 took up histamine from the microenvironment, it was unclear which transporter mediated its passage across the plasma membrane. Other biogenic amines have selective transporters that belong to the neurotransmitter sodium symporter family, including SERT fo

• In the current study Olfml knockdown

  2022-04-29

  

  In the current study, Olfml1 knockdown increased YAP but decreased the respective target genes of canonical Wnt signaling and Hedgehog signaling, Axin2 and Gli1. YAP suppresses canonical Wnt via binding to Dishevelled and/or β-catenin [[39], [40], [41], [42]]. Tariki et al. reported that adenovirus-

• Spindle positioning is governed by the actin cytoskeleton

  2022-04-29

  

  Spindle positioning is governed by the actin cytoskeleton. After a transient metaphase arrest, cells lacking haspin exhibit a misdistribution of actin, which accumulates within the bud. Actin dynamics is modulated by an intricate network including septins, the polarisome complex, and formins. We sho

• To characterize the basic functions of GPR

  2022-04-29

  

  To characterize the basic functions of GPR84 in phagocytes, we have utilized the receptor selective antagonist GLPG1205 (a small selective antagonist of GPR84 developed by Galapagos NV [14]) together with ZQ16 (2-(hexylthio) pyrimidine-4,6-diol), a potent GPR84 selective agonist identified in a high

• Fig summarizes the underlying mechanism of SB on

  2022-04-26

  

  Fig. 7 summarizes the underlying mechanism of SB on inhibiting inflammation and maintaining epithelium barrier integrity in the TNBS-induced colitis model. Our findings not only explained the protective effect of SB on colon health, but also provided evidence that GPR109A likely constitutes a valid

• br Significant efforts are currently focused on non

  2022-04-26

  

  Significant efforts are currently focused on non-dopaminergic strategies to address the unmet medical needs in schizophrenia, and targeting -methyl--aspartate (NMDA) ABT 702 dihydrochloride hypofunction has garnered a great deal of attention., , Elevation of synaptic glycine levels near NMDA-cont

15746 records 430/1050 page Previous Next First page 上5页 426427428429430 下5页 Last page