• Introduction Initially postulated to represent the main

  2022-05-19

  

  Introduction Initially postulated to represent the main source of ATP production in eukaryotic cells, mitochondria are recently recognized to perform manifold essential functions beyond energy production, impacting most areas of cell biology and medicine [1]. Mitochondrial metabolism is both the ba

• br FXR FGF in the control of BAs synthesis The

  2022-05-19

  

  FXR–FGF15/19 in the control of BAs synthesis The nuclear receptor FXR is the master regulator of BAs homeostasis, modulating their synthesis, trpv1 antagonist and uptake [15]. FXR decreases BA de novo hepatic biosynthesis by reducing the expression of CYP7A1. At the canalicular membrane, newly-s

• Polyunsaturated fatty acids PUFAs represent a

  2022-05-19

  

  Polyunsaturated fatty acids (PUFAs) represent a class of lipids that contain two or more carbon double (unsaturated) bonds (CC) and classified as n-3, n-6 and n-9 fatty acids. PUFAs including n-3 such as docosahexaenoic Phosphocreatine disodium salt (DHA), eicosapentaenoic acid (EPA) and n-6 such a

• br Ferroptosis modulators With the recognition that

  2022-05-19

  

  Ferroptosis modulators With the recognition that the small molecule erastin targets system xc- and thereby specifically triggers this form of death and that ferrostatin-1 prevents erastin-induced ferroptosis [2], it has become evident that ferroptosis is a druggable pathway with a number of tract

• The current lack of effective treatments for

  2022-05-19

  

  The current lack of effective treatments for primary or metastatic UM leaves a large therapeutic gap for patients and clinicians underscoring an urgent need for the identification of additional pharmacological targets for therapeutic intervention. As YAP-targeting strategies have remained elusive th

• Senger et al performed a retrospective review

  2022-05-19

  

  Senger et al. performed a retrospective review of 17 patients with ICH on dabigatran or rivaroxaban who received 4F-PCC. Eight patients had a traumatic SAR405838 injury (TBI) and nine patients had a spontaneous ICH. Nine patients had a devastating outcome, including severe neurologic deficits, coma

• br STAR Methods br Acknowledgments We

  2022-05-19

  

  STAR★Methods Acknowledgments We thank the Shanghai Synchrotron Radiation Facility (SSRF) BL18U for help with X-ray data collection. We thank Dr. Thomas F.J. Martin for providing the pcDNA3.1-CAPS-1 plasmid and Dr. Xiaofei Yang for providing the pFHUUIG_shortU6 (l309) plasmid. We thank Dr. Shun

• br Dynamic Localization of Hippo Pathway Components The obse

  2022-05-19

  

  Dynamic Localization of Hippo Pathway Components The observation that Wts normally localizes with an inhibitor, Jub, raised the question of how and where Wts normally becomes activated. Under conditions of pathway activation in Drosophila imaginal discs, Wts relocalized from Jub to Ex, where it i

• The RAS RAF MEK ERK pathway is a

  2022-05-19

  

  The RAS/RAF/MEK/ERK pathway is a central controller of cell proliferation and survival and, consequently, alterations to some of its components lead to hyperactivation of the pathway, an event related to numerous types of cancer [172]. High rates of alterations to this pathway are found in leukemia,

• ICLs represent of all generated DNA adducts for cisplatin an

  2022-05-19

  

  ICLs represent ICL Inducers in Cancer Therapy Nitrogen mustards with aromatic substituents (chlorambucil, melphalan) or a bioactivatable phosphoramide group (cyclophosphamide) were one of the first identified DNA crosslinkers. These agents are still used in combined schemes for the therapy of chr

• The importance of FXR FGF signaling in BA homeostasis is

  2022-05-18

  

  The importance of FXR-FGF15/19 signaling in BA homeostasis is illustrated by various BA malabsorption syndromes. Clinically, BA malabsorption causes diarrhea due to high BA concentrations in the colon that lead to secretion of water and electrolytes and stimulation of propulsive contractions [36]. P

• Diabetes induced damage results in peripheral nerve

  2022-05-18

  

  Diabetes-induced damage results in peripheral nerve pathology that PU-H71 correlates with clinical signs and symptoms. Nerve injury that results in structural changes can be measured through clinical neurological assessment, quantitative sensory testing, nerve conduction studies, and peripheral ner

• Cytarabine Studies examining cerebral glucose metabolism in

  2022-05-18

  

  Studies examining cerebral glucose metabolism in MDD using 18 F-fluorodeoxyglucose in positron emission tomography (FDG-PET) showed altered regional glucose metabolism in MDD (Dunn et al., 2002, Kennedy et al., 2001, Kimbrell et al., 2002, Saxena et al., 2001). In a recent meta-analysis by Su and co

• When PKC was applied alone it attenuated

  2022-05-18

  

  When PKC19–31 was applied alone, it attenuated the activity run-down following excision. Furthermore, the activity induced by addition of PKC19–31 during PMA treatment in many cases was higher than in controls. Accordingly, in our experimental conditions, the mechanism which underlays channel inhibi

• Isoflurane administration during i t procedures can complica

  2022-05-17

  

  Isoflurane administration during i.t. procedures can complicate the interpretation of our results since isoflurane has been shown to have both neuroprotective and neurotoxic effects (Jiang et al., 2017). Isoflurane pretreatment has been implicated as having protective effects in ischemia in animal m

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