• Freinkel first reported in the

  2022-06-28

  

  Freinkel first reported in the late 1960s that maternal hypertriglyceridemia benefits the fetus during starvation by increasing maternal consumption of triglyceride for ketone body synthesis giving the basis for “accelerated starvation” theory [4,5]. This maternal metabolic reprogramming during peri

• HOs can be found in both

  2022-06-28

  

  HOs can be found in both plants and animals and they are evolutionarily conserved proteins [8]. There are two HO isoenzymes: inducible heme oxygenase-1 (HO-1) and constitutive heme oxygenase-2 (HO-2) encoded by different genes [9,10]. Biosynthesis of a stress-inducible HO-1 can be triggered by a var

• We also conducted analyses on the functional category of UP

  2022-06-28

  

  We also conducted analyses on the functional category of UP_Keywords and on KEGG pathways for further understanding. The UP_Keywords analysis (D) demonstrated that acetylation and phosphoprotein were highly enriched categories. KEGG pathways categories (E) of ribosome biogenesis in eukaryotes, DNA

• br Conclusion and future perspectives In the

  2022-06-28

  

  Conclusion and future perspectives In the setting of myocardial I/R stress, HDAC activity is induced and contributes to myocardial injury. HDAC inhibition appears to protect the Z-WEHD-FMK mg from I/R injury by activating a variety of pro-survival molecular pathways. From a clinical relevance sta

• In plants NO production is one of the early

  2022-06-28

  

  In plants, NO production is one of the early responses to stress (Tossi, Lamattina, & Cassia, 2009). Usually, NO signal transduction requires the involvement of downstream signaling compounds. We further investigated the effects of cGMP on GSK-3 expression. The data showed that LY83583 (a cGMP inhib

• br Activity dependent control of myelination and

  2022-06-28

  

  Activity-dependent control of myelination and myelin maintenance Oligodendrocytes have intrinsic myelinating capacity and can myelinate fixed PCI-34051 in addition to synthetic nanofibers and micropillars [21, 34, 35]. What prevents oligodendrocytes from myelinating dendrites or other cells in th

• br Materials and methods br Results br

  2022-06-28

  

  Materials and methods Results Discussion Nervous system disease is an important signal of AIDS deterioration (Rosca et al., 2012, Yilmaz et al., 2012). It is possible that HIV crosses the blood CAY10499 barrier or blood cerebrospinal fluid barrier into the central nervous system freely or

• br Acknowledgements br Introduction Obesity is a growing pan

  2022-06-28

  

  Acknowledgements Introduction Obesity is a growing pandemic, which becomes a global public health problem. The evidence has been readily available and mounting, demonstrating that obesity increases incidences of chronic comorbidities, such as non-alcoholic fatty liver diseases, diabetes, cardi

• k j and d were

  2022-06-28

  

  15k, 15j and 14d, were then submitted to metabolic stability studies in human and mouse liver microsomes and permeability test with Caco-2 cells (Table 7). 15k, 15j and 14d all retained excellent permeability (Papp value greater than 15.2 × 10−6 cm/s) and displayed modestly improved metabolic stabil

• To assess whether this coupling mechanisms might

  2022-06-28

  

  To assess whether this coupling mechanisms might operate also in a native system of untransfected cells, we select a cell line SH-SY5Y neuroblastoma that is known to express both the dopamine transporter and the M-currents (Jiang et al., 2004; Wickenden et al., 2008). These experiments were performe

• Epidemiological evidence indicates that neuroinflammation pl

  2022-06-28

  

  Epidemiological evidence indicates that neuroinflammation plays a pivotal role in pathogenesis of AD (Heneka et al., 2015, Heneka et al., 2013, Holmes et al., 2009, Liu et al., 2016). For example, prolonged treatment with nonsteroidal anti-inflammatory drugs reduces the risk of developing AD (In et

• br Conclusion br Conflict of interest br Acknowledgments

  2022-06-28

  

  Conclusion Conflict of interest Acknowledgments This work was supported by an NRF grant (2016R1A2B4011196) from the Korea Research Foundation. Introduction Thymic epithelial tumors are rare, but they are the most common primary neoplasm of the thymus and of the anterosuperior mediastinu

• The role for noggin in telencephalic development and also ad

  2022-06-28

  

  The role for noggin in telencephalic development and also adult neural stem cell expansion and differentiation has been debated, and noggin has been suggested to exert diverse effects in these events (Bachiller et al., 2000, Bonaguidi et al., 2008, Colak et al., 2008; de Chevigny et al., 2008, Li et

• mcc950 br Results and discussion br Conclusion In conclusion

  2022-06-27

  

  Results and discussion Conclusion In conclusion, twenty-one 4-monocyclic aryl-5-carbamoyl-3-isoxazolols have been synthesized and evaluated for their antagonistic activities against housefly and common cutworm GABARs expressed in Xenopus oocytes. The TEVC results indicated that mcc950 several

• br Conclusions In this study we discovered that the

  2022-06-27

  

  Conclusions In this study, we discovered that the G-quadruplex (Q1) formed by S1 sequence in the upstream region of the transcription start site of c-Myb gene functioned as a positive transcriptional regulator, which was different from the most cases that G-rich sequences functioned to impair the

15746 records 396/1050 page Previous Next First page 上5页 396397398399400 下5页 Last page