• Accumulating evidence suggest that patients with advanced po

  2023-02-06

  

  Accumulating evidence suggest that patients with advanced -positive NSCLC are at increased risk of VTE or coagulation disorders during the course of their disease, indicating that cancer genotype might play a role in the occurrence of cancer-related thromboembolism . Here we report the case of a pat

• CYP A is one of the key

  2023-02-01

  

  CYP3A4 is one of the key metabolizing Z-Ligustilide receptor of the cytochrome P450 (CYP) superfamily of heme-containing monooxygenases. As the CYP family of enzymes plays important roles not only in the xenobiotic metabolism and detoxification of a large number of drugs, but also in the biosynthes

• mk 801 The H N mutation in

  2023-02-01

  

  The H373N mutation in exon 6 has not previously been reported [3], [4], [5], [6]; thus, this mutation appears to be a novel mutation. The functional expression study demonstrated that the H373N mutation results in almost complete loss of enzymatic activity. Thus, it is highly likely that the H373N m

• In the current study we provide evidence that

  2023-02-01

  

  In the current study, we provide evidence that enhanced ATX activity correlates well with increased ATX protein concentration during cholestasis and pregnancy (Fig. 1). Hereby we have ruled out the possibility of ATX enzyme activation in these conditions, e.g. by circulating cholephiles. ATX clearan

• br Results br Discussion The A nidulans Aurora kinase displa

  2023-02-01

  

  Results Discussion The A. nidulans Aurora kinase displays diverse locations during mitosis and we show here that it also locates to hyphal regions where septa subsequently form, to the septal pore region of newly formed septa and displays a ARQ 621 australia specific location to mature septa.

• Given the recent discovery of regions

  2023-02-01

  

  Given the recent discovery of regions of single-stranded DNA in the nuclei of hypoxic cells, the role for ATR in the response to hypoxic stress seems clearer . Zou and Elledge demonstrated that both Ddc 2 (the homolog of ATRIP) and ATRIP have a lower affinity for double-strand breaks than they do f

• In the current study SA

  2023-02-01

  

  In the current study, SA was assessed to confirm the safety of CS addition to erythrocytes SA as well as SA elicits antioxidant action. It has been reported that, ROS induced desialylation by depletion of SA content from cell surfaces (Pawluczyk et al., 2014, Harisa, 2015). Therefore, significant de

• This study evaluated the anti tumor

  2023-02-01

  

  This study evaluated the anti-tumor influences of LA against HepG2 cAMPS-Rp, triethylammonium salt in vivro, and investigated the molecular mechanisms of inducing apoptosis. Overall, our studies suggested that LA is a promising anti-cancer drug and a possible novel therapeutic agent directed toward

• AP plays a pivotal role

  2023-02-01

  

  AP-1 plays a pivotal role in transcriptional regulation of MMP expression. The decoy technique allows the neutralization of AP-1 without any transfection reagents for cellular uptake that cause potential side effects or immune reactions. This energy-dependent transport mechanism of “naked” dODN is c

• We report here the case of a patient with

  2023-02-01

  

  We report here the case of a patient with probable genetic prion disease with a Creutzfeldt-Jakob disease-like phenotype associated with a rare PRNP E196K mutation who initially exhibited atypical clinical manifestations principally characterized by behavioral abnormalities. Case report An 80-ye

• Testosterone can be converted into estrogens by

  2023-02-01

  

  Testosterone can be converted into estrogens by aromatase action. Aromatase is encoded by CYP19, belongs to cytochrome P450 superfamily, and synthesizes estradiol (E2) and estrone (E1) from testosterone and androstenedione respectively (Fig. 1). Aromatase is expressed in the ORS of anagen hair folli

• Intracellular Signaling Cascades From ligand

  2023-02-01

  

  Intracellular Signaling Cascades. From ligand sensitization to translation of genes, all cellular processes are dependent on the intracellular levels and activity of partners involved in the signaling pathway. These signaling events lead to critical post-translational modifications including phospho

• In our sequential model for tau and A deposition we

  2023-02-01

  

  In our sequential model for tau and Aβ deposition, we included the tau deposition in the medial temporal Tacrolimus in the absence of Aβ deposition, which is a pathological definition of primary age-related tauopathy (PART). Although the tau pathologies in PART and AD are almost identical in their

• Ala a branched chain amino acid has been

  2023-02-01

  

  Ala, a branched chain amino acid, has been reported to play a functional role in intracellular pH regulation, and it typically accumulates in response to various stresses (Limami et al., 2008, Rocha et al., 2010). Our data demonstrated that increasing Cd concentrations at lower Cd doses resulted in

• The correlation in the increase

  2023-02-01

  

  The correlation in the increase of BADH mRNA, protein levels, and enzyme activity, demonstrate that oxidation of betaine aldehyde by BADH is primordial to regulate the GB accumulation during physiological cardiac hypertrophy induced by pregnancy, this implies a major role because GB levels enhance c

16387 records 362/1093 page Previous Next First page 上5页 361362363364365 下5页 Last page