• The major phase trial NCT enrolled

  2023-09-01

  

  The major phase 2 trial (NCT01343966) enrolled 431 participants with mild to moderate AD who received either low-dose SC crenezumab 300 mg or placebo biweekly (n = 184) or high-dose intravenous crenezumab 15 mg/kg or placebo every 4 weeks (n = 247) for 68 weeks 38, 40. No significant treatment bene

• Aberrant lipid levels are associated with various

  2023-09-01

  

  Aberrant lipid levels are associated with various disorders, including vascular diseases and diabetes. Furthermore, important events support the idea that lipids, especially cholesterol and its derivatives, have a fundamental role in the physiopathology of AD. The recombinant insulin is rich in chol

• Di ethylhexyl phthalate DEHP is one of the most widely

  2023-09-01

  

  Di-(2-ethylhexyl) phthalate (DEHP) is one of the most widely used environmental chemicals in the production of polyvinyl chloride. After 340 7 sale into human body, DEHP can be converted to the metabolite mono-ethylhexyl phthalate (MEHP), which has higher toxicity than DEHP and can influence reprod

• Since the cloning of ARs in

  2023-09-01

  

  Since the cloning of ARs in the beginning of the 1990s, the efforts to characterize them have led to the accumulation of a substantial amount of experimental data. Decades of site-directed mutagenesis (SDM; Box 1) studies, in combination with pharmacological data and computational modeling, have pav

• Introduction Pyometra is relatively common in intact

  2023-09-01

  

  Introduction Pyometra is relatively common in intact bitches and its diagnosis is aided by ultrasonography (Bigliardi et al., 2004), along with measurement of acute phase proteins and leucocyte (white blood cell, WBC) counts; assessment of these parameters during recovery may be helpful for monitor

• Whereas more research is needed to identify the

  2023-08-31

  

  Whereas more research is needed to identify the precise mechanism by which FIN exerts its antidyskinetic effect, the Fomepizole that it can negatively modulate dopaminergic transmission is also supported by our previous findings. Indeed, we have previously shown that FIN completely reversed the beha

• As mentioned above variation of the A

  2023-08-31

  

  As mentioned above, variation of the A-ring was undertaken in order to improve microsomal stability and kinase selectivity relative to Sennoside C (). 1-Imidazole-2-carboxamides with substitution at the 4-position (–) were mostly tolerated with 4-cyano-imidazole-2-carboxamide () having comparable i

• Having established the structural requirements for potency i

  2023-08-31

  

  Having established the structural requirements for potency in both the biochemical and biomarker (CRA) assays, we evaluated key compounds in the metabolic stability assay. Disappointingly, we found that all compounds had high intrinsic clearances in mouse microsomes. To ascertain whether the in vitr

• br Materials and methods br Results br

  2023-08-31

  

  Materials and methods Results Discussion Recent studies have highlighted IL-10, human recombinant protein sale and autophagy as novel targets for the treatment of liver fibrosis [7,14]. In this study, we demonstrated that catalpol protected the rat liver from CCl4-caused injury and fibroge

• br Materials and methods br

  2023-08-31

  

  Materials and methods Results Discussion Despite the relative complexity of immunotherapy, such treatment may have an important role, in conjunction with other therapies in the treatment of cancer refractory to conventional treatments alone. Clinical studies have recently shown that adding

• MiR has already been implicated in the protective

  2023-08-31

  

  MiR-21 has already been implicated in the protective effects of Res on lung fibrosis, but the molecular mechanisms are underexplored. Our results showed a clear increase of activation protein 1 (AP-1) activity after TGF-β treatment, which was suppressed by Res in a dose-dependent manner, suggesting

• Bamboo shoots with their high nutritive http www

  2023-08-31

  

  Bamboo shoots, with their high nutritive and therapeutic value, are now used for food fortification (Nirmala & Bisht, 2017). Several value-added products such as nuggets, crackers, chutney, snacks, cookies, cakes, chappaties, and buns have been prepared from bamboo shoots (Table 3). Dietary fiber fr

• br Results A total of

  2023-08-31

  

  Results A total of 126 respondents completed the survey (68.5% response rate), with at least 65% response rate from each of the four represented sectors (denominators represent the total constituent body of the organization or the total attendees of the meeting): PUC 24 out of 37 (65%), SPUNZA 33

• Interestingly all of the ROS rearrangements share a constant

  2023-08-31

  

  Interestingly, all of the ROS1 rearrangements share a constant breakpoint in ROS1 and the fusion product contain the kinase domain resulting in aberrant ROS1 expression with constitutive kinase activity. Intrachromosomal deletions and interchromosomal translocations have demonstrated the existence o

• OCT also is known as POU F plays an

  2023-08-31

  

  OCT4 (also is known as POU5F1) plays an important role in embryonic stem cell self-renewal, development and reprogram somatic cell into pluripotent stem cell [[5], [6], [7]]. Recently, many studies also find OCT4 promotes the progression of many tumors. For example, Wnt/β-catenin promotes the expans

15714 records 246/1048 page Previous Next First page 上5页 246247248249250 下5页 Last page