• In summary using the Nurr agonist AQ we first showed

  2018-10-20

  

  In summary, using the Nurr1 agonist AQ we first showed that Nurr1 plays an important role in the regulation of adult hippocampal neurogenesis. AQ may increase adult hippocampal neurogenesis via, in part, an up-regulated phosphorylation of Akt and ERK1/2. Moreover, the Nurr1 agonist enhances both sho

• br Material methods br Results br Discussion br

  2018-10-20

  

  Material & methods Results Discussion Acknowledgements We thank Melissa Carballosa-Gautam in the Miami Project to Cure Paralysis Imaging Core. This design, experimentation, data analysis and manuscript writing was supported by the Miami Project to Cure Paralysis; NIH/NINDS (DJL: NS049545

• Our studies show that only a subpopulation of hESCs

  2018-10-20

  

  Our studies show that only a subpopulation of hESCs at the top of the hierarchy possesses an extensive capacity for self-renewal. Polanco et al. recently showed that glutathione s-transferase in this compartment could reestablish the continuum of cell states seen in unfractionated cultures (Polanco

• Cell transplantation therapy is a promising approach to prom

  2018-10-20

  

  Cell transplantation therapy is a promising approach to promote remyelination in MS patients; human embryonic stem salubrinal (hESCs) and induced pluripotent stem cells, as well as fetal brain, are potential sources of therapeutic cells (Brüstle et al., 1999; Müller et al., 2006). Studies in animal

• We have demonstrated that donor specific DNAm patterns are

  2018-10-20

  

  We have demonstrated that donor-specific DNAm patterns are maintained upon reprogramming into iPSCs (Shao et al., 2013), and these also remain upon redifferentiation into iPS-MSCs. Thus, there is some epigenetic memory after chromatin remodeling—whether these donor-specific DNAm patterns are functio

• br Results We investigated the identity

  2018-10-20

  

  Results We investigated the identity of human NPCs extracted from the foreskin dermis through fluorescence-activated cell sorting (FACS)-based isolation of cell subpopulations and subsequent characterization of the sorted chemokine receptor (Figure 1). Immunofluorescent and flow-cytometry analys

• Based on their well documented activity

  2018-10-20

  

  Based on their well-documented activity profile, we employed M-CSF and G-CSF to direct terminal myeloid differentiation toward the monocyte/macrophage or granulocyte lineage in our studies. We found that the IL-3/M-CSF combination efficiently promoted the differentiation of iPSCs into iPSC-MΦ that r

• br Results br Discussion We

  2018-10-20

  

  Results Discussion We have established a novel serum-free culture method for generating and expanding CD271+CD73+SOX9+ chondrogenic ectomesenchymal trpv1 from hPSC-derived, CD271hiCD73− neural crest-like progeny. The differentiation pathways from hPSCs to chondrocytes via chondrogenic ectomes

• Ectopic BMP signaling activates the primitive erythroid prog

  2018-10-20

  

  Ectopic BMP signaling activates the primitive erythroid program, while inhibiting the pathway blocks ventral blood island formation in Xenopus (Zhang and Evans, 1996). This suggests that BMP signaling may represent a critical influence on erythroid differentiation, in addition to its role in mesoder

• br Introduction Glioblastoma GBM is the most

  2018-10-20

  

  Introduction Glioblastoma (GBM) is the most common primary malignant TH-302 tumor in adults. Despite multimodal aggressive therapies, survival of a vast majority of the patients is less than 2 years with the 5-year survival rate as low as 5% (Stupp et al., 2009). Previous efforts in the developme

• br Disclosure of potential conflicts of interest br

  2018-10-20

  

  Disclosure of potential conflicts of interest Acknowledgements Introduction In many cells, the plasma membrane and underlying topotecan Supplier filaments interact dynamically with each other to produce cell surface blebs, which may be either dynamic (non-apoptotic) or apoptotic (Weng, 2016

• All PGCs differentiated from ESCs

  2018-10-20

  

  All PGCs differentiated from ESCs in our study, regardless of differentiation approach or sorting strategy, were capable of implementing ICC erasure at the Snprn ICC. However, unlike E9.5 PGCs from the embryo, the hypomethylated state at this ICC was unstable, and in every case re-methylation was in

• We next aimed to characterize changes in

  2018-10-20

  

  We next aimed to characterize changes in huSCs during ex vivo culture, which, in mice, results in a marked reduction in the capacity for tissue regeneration and self-renewal upon subsequent transplantation (Gilbert et al., 2010; Montarras et al., 2005). For this analysis, we used a basal culture med

• br Results br Discussion In this study we provide

  2018-10-20

  

  Results Discussion In this study we provide several lines of evidence that Dnd serves as a critical PGC specifier in medaka. First, dnd knockdown is capable of specifically and completely abolishing PGC formation and its overexpression is sufficiently capable of inducing ectopic PGCs in embry

• Zscan is sometimes considered as a marker of

  2018-10-20

  

  Zscan4 is sometimes considered as a marker of highly pluripotent status, merely due to its expression at the two-cell stage during development (Cerulo et al., 2014). However, based on our observation, we would like to propose that the expression of Zscan4 is activated in response to telomere shorten

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