• A concern for many potential inhibitors

  2018-11-09

  

  A concern for many potential inhibitors of restenosis is that their anti-proliferative effects are not specific to SMC and can therefore also inhibit proliferation of endothelial cells (EC) that line the lumen. Delayed re-endothelialization of the treated area creates a thrombogenic surface for plat

• Our findings indicate that rat

  2018-11-08

  

  Our findings indicate that rat ESCs are more sensitive to GSK inhibition primarily because of the relative abundance of LEF1, which favors the activation of differentiation genes. Their collective expression may challenge and destabilize the self-renewal circuitry. The TOPFlash assays also suggest t

• Besides their direct effect on cartilage ASCs might act on

  2018-11-08

  

  Besides their direct effect on cartilage, ASCs might act on the other joint tissues as synovial membrane, ligaments, meniscus and subchondral bone that are also altered in OA. Although OA is not considered an inflammatory disease, pro-inflammatory cytokines, namely IL-1β and TNF-α, are secreted by O

• Taken together we conclude that Lats may regulate adult card

  2018-11-08

  

  Taken together, we conclude that Lats may regulate adult cardiomyocyte hypertrophy independent of Yap or Tead1. Rather than controlling cardiac hypertrophic growth, the canonical Hippo/Yap pathway is crucial for regulation of cardiomyocyte survival in the adult heart. This parallels the findings in

• Based on our results we propose a panel of

  2018-11-08

  

  Based on our results, we propose a panel of potential hiPSC protein markers from the above-mentioned 22 proteins (Supplementary Table 12). We intentionally used three previously characterized stem cell lines (hiPSC: iNC-01, SB5-MP1 and hESC-H9) in our proteomic study. The genomic methylation profile

• The main drawback of NSC based

  2018-11-08

  

  The main drawback of NSC-based anti-tumor therapies is that, despite the effective tumor tropism exhibited by NSCs, only small portions of transplanted cells can migrate towards the tumor. Several recent publications have revealed that 70–80% tumor volume reduction can be achieved in various orthoto

• br Materials and methods br Statistical analysis Data are pr

  2018-11-08

  

  Materials and methods Statistical analysis Data are presented as mean±SEM. Differences between groups were detected for statistical significance using the unpaired Student\'s t-test. P Results Discussion We have previously postulated that Hopx might label NSCs in the dentate gyrus based u

• MAPK Inhibitor Library br Conclusion In summary we provided

  2018-11-08

  

  Conclusion In summary, we provided the first evidence that FOXM1 plays an important role in the maintenance of cell proliferation in the hESC cell line VAL-3, with significant functions in safe-guarding progression through G2/M phase mediated by the transcriptional regulation of MAPK Inhibitor Li

• Although our model supported viral

  2018-11-08

  

  Although our model supported viral life cycle, there were key elements of the system that required more detailed attention. Despite robust infection, hESC-Heps and primary hepatocytes produce less infectious virions than Huh7 line (Liang et al., 2009; Ploss et al., 2010; Podevin et al., 2010; Roelan

• In addition to demonstrating how the cryopreservation and th

  2018-11-08

  

  In addition to demonstrating how the cryopreservation and thawing process impacts the binding characteristics of MSCs, we observed that viability can vary substantially depending on the assay employed. In this work, we utilized several methods to determine cell viability, which yielded different res

• In conclusion the Olfm IRES

  2018-11-08

  

  In conclusion, the Olfm4-IRES-eGFPCreERT2 allele described here provides a tool, separate from Lgr5, that can be used to further characterize intestinal stem cells. Experimental Procedures Acknowledgments We thank Hugo Snippert for analysis of the Olfm4 animals and Valentina Sasselli for a cr

• In this work we developed multiple tools

  2018-11-08

  

  In this work, we developed multiple tools to interrogate this autocrine and paracrine signaling loop involving α-5 laminin production by hPSCs. The use of the inducible short hairpin lines allowed us to control the dynamics of α-5 laminin production in a reversible manner. However, the interpretatio

• br Experimental Procedures An expanded

  2018-11-08

  

  Experimental Procedures An expanded version of the Experimental Procedures appears in the Supplemental Information. Author Contributions All experiments were performed at the University of Washington in Seattle, WA, USA. J.M.P. designed the method, performed cell differentiation and all exper

• Silmitasertib cost br Results br Discussion The range of cel

  2018-11-07

  

  Results Discussion The range of cell types in Haemopedia makes identification of lineage-specific genes more rigorous. The genes that we have identified as lineage signatures are highly specific to each lineage and are lineage specific in other datasets (Figure S5). This provides a powerful re

• br Experimental Procedures br Author Contributions

  2018-11-07

  

  Experimental Procedures Author Contributions O.G. performed the analysis, visualization, qRT-PCR, and writing of the manuscript; K.M. carried out Hlf functional experiments; N.B. helped with the computational analysis; Y.G. performed the cell culture and functional assays; M.F. did some of the

16361 records 1072/1091 page Previous Next First page 上5页 10711072107310741075 下5页 Last page