• The rationale for use of FASN inhibitors as a key

  2018-11-14

  

  The rationale for use of FASN inhibitors as a key component of combination therapy derives from known cellular effects of FASN inhibition (Ventura et al., 2015; Chuang et al., 2011; Kridel, 2004; Puig et al., 2009, 2008; Tomek et al., 2011) that include (1) blockade of palmitate synthesis, (2) disru

• Workflow Mascot Distiller Mascot Skyline

  2018-11-14

  

  Workflow 8: Mascot Distiller/Mascot/Skyline/MS Signal analysis. Peaklist creation was performed with Mascot Distiller as described in workflow 3, then database searches were performed with Mascot and validated with Scaffold as described for workflow 4. XIC signal corresponding to all validated pepti

• Previous evidences indicate that EDS

  2018-11-13

  

  Previous evidences indicate that EDS and SOS episodes have a different pattern of manifestation in PD. For instance, EDS is frequently found [7]; otherwise, SOS is less common and manifests somewhat similar to narcoleptic events [8]. Of note, the extent and severity of SOS in PD is variable: some pa

• During summers and winters in Antarctica the most extreme an

  2018-11-13

  

  During summers and winters in Antarctica, the most extreme and isolated continent on earth, the human circadian clock cannot rely on changes of photoperiod and temperature to entrain the clock day after day, and circadian rhythms might tend to free run [17]. Sleep disorders reported in Antarctic cre

• The contemporary physicians have more knowledge

  2018-11-13

  

  The contemporary physicians have more knowledge about this condition, and in the diagnosis and in therapeutic choices, given that the treatment should be individualized for each patient. The high costs of the treatments, the lack of therapeutic adherence as well as inadequate compliance of the patie

• br Materials and methods br Results and discussion

  2018-11-13

  

  Materials and methods Results and discussion Conclusion Our previous publications have established a five month-long stable C-FBN-C on a microelectrical array as a C-FBN-biosensor [10,11] and characterized it pharmacologically by investigating its responsiveness to Mg, TTX, and VER ([12], i

• Jalisco se encuentra entre los estados con mayores niveles e

  2018-11-13

  

  Jalisco se encuentra entre los estados con mayores niveles educativos, de formación profesional y empleo de trabajadores del conocimiento, en tecnologías de la información y la comunicación en el país. En la ocupación de especialistas formados en carreras relacionadas con ingeniería en computación e

• br El salario m nimo en M xico

  2018-11-13

  

  El salario mínimo en México y América Latina En los últimos setenta años la evolución del salario mínimo en términos reales en nuestro país ha tenido tres grandes etapas asociadas, en alguna medida, al desempeño de la economía mexicana. En la primera etapa que va desde la década de 1950 hasta la

• br Las bases y los fundamentos de

  2018-11-13

  

  Las bases y los fundamentos de la intervención pública en la actividad económica De manera específica, Kalecki argumentó que el sistema capitalista es inestable y provoca condiciones de subempleo porque no hay seguridad que el gasto capitalista (consumo e inversión privada) sea suficiente para em

• El cuadro muestra los resultados

  2018-11-13

  

  El cuadro 5 muestra los resultados de las estimaciones de largo plazo del modelo ardl empleado. El coeficiente de la ied es negativo y significativo en el sector primario, lo que implica que las inversiones extranjeras reducen, en general, el empleo en las actividades agrícolas, forestales, ganadera

• Esa diferencia en la forma particular de inserci n

  2018-11-13

  

  Esa diferencia en la forma particular de inserción a la nueva fase o –vía de desarrollo– se expresa en distintas formas de Estado y su accionar en la reproducción y el desarrollo económico; situación que ha dado lugar a la emergencia de antiguas y nuevas potencias económicas, como es el caso de Chin

• In a recent paper Montiel and S

  2018-11-13

  

  In a recent paper, Montiel and Sérven (2008) point out the increasing number of advocates of the notion that the level of the real exchange rate has important effects on growth because it affects capital accumulation. For Bresser-Pereira and Gala (2007) there usually exists a high rate of substituti

• Introduction Recent years have witnessed a vast development

  2018-11-13

  

  Introduction Recent years have witnessed a vast development of nonlinear techniques for modelling the conditional mean and conditional variance of economic and financial time series. In the vast array of new technical developments for conditional mean models, the Smooth Transition AutoRegressive (S

• Note that the two functional

  2018-11-13

  

  Note that the two functional forms of the inflation tax curve are obtained as particular cases of the following function: The two particular cases are as follows: (a) constant semi-elasticity: a1=1, a2>0; constant elasticity: a2=0. The functional form (13) also encompasses other possibilities that

• In this paper after this introduction

  2018-11-13

  

  In this paper, after this introduction, we deal with the oversight just mentioned. An alternative treatment is given to the existence of a proper solution involving a Hypercube Graph, which we call, by analogy with the magic square, the magic hypercube. In order for this paper to be self-contained,

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