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s6 kinase During the tooth morphogenesis growth factors and
2018-11-12
During the tooth morphogenesis, growth factors and other paracrine signal molecules mediate the interactions both between and within the epithelial and mesenchymal tissues, such as the fibroblast growth factors (FGFs), transforming growth factors (TGFs), bone morphogenetic proteins (BMPs), and insul
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br Discussion Since the derivation of HESCs
2018-11-12
Discussion Since the derivation of HESCs multiple differentiation protocols towards specific endodermal derivatives have been established (D\'Amour et al., 2006; Jiang et al., 2007a, 2007b; Shim et al., 2007; Roelandt et al., 2010; Si-Tayeb et al., 2010; Van Vranken et al., 2007; Wang et al., 200
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br Introduction Breast cancer is a
2018-11-12
Introduction Breast cancer is a heterogeneous disease characterized by at least eighteen histopathological and six distinct molecular subtypes, making it extremely difficult to treat (Sørlie et al., 2001). This phenotypic diversity is considered to reflect the epithelial lineage from which a give
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Recently inherently tumor tropic stem cells have received a
2018-11-12
Recently, inherently tumor-tropic stem cells have received a great deal of attention for their clinical potential to treat diverse human cancers. For example, hNSCs are reported to be very effective in delivering various therapeutic agents in preclinical models of malignant pmpa tumors including me
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http www ncbi nlm nih gov eleen
2018-11-12
(http://www.ncbi.nlm.nih.gov.eleen.top/geo/query/acc.cgi?token=rfopdesiwmqiepk&acc=GSE31413) Introduction The process of differentiation of mammalian embryonic stem cells (ESCs) involves an increasing restriction in proliferative capacity (Nichols and Smith, 2009), ending in jnk inhibitor exit
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br Introduction The mammary tissue undergoes extensive morph
2018-11-12
Introduction The mammary tissue undergoes extensive morphological and phenotypic alterations during the pregnancy/lactation cycle forming a complex network of alveolar structures (Rosen et al., 1994; Macias and Hinck, 2012). This cellular architecture exhibits well defined A/B polarization establ
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Serelaxin RLN a recombinantly produced peptide based on the
2018-11-12
Serelaxin (RLN; a recombinantly-produced peptide based on the human gene-2 (H2) relaxin sequence; which represents the major stored and circulating form of human relaxin) exerts potent anti-fibrotic actions in the airways/lung (Bennett, 2009; Huang et al., 2011; Kenyon, Ward, and Last, 2003; Royce e
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br Introduction Cardiac and skeletal myogenesis both generat
2018-11-09
Introduction Cardiac and skeletal myogenesis both generate striated muscle, but are traditionally thought of as two separate processes with distinct developmental anlagen. However, recent work suggests the existence of at least one bipotent anlage for cardiac and skeletal muscle: the common proge
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The value of can be significantly lower
2018-11-09
The value of can be significantly lower than the initial elastic modulus of the material containing no hydrogen, as The above equation clearly illustrates the strong effect that the concentration of the attached hydrogen particles has on the total elastic modulus: the higher the proportion of t
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where and are the effective densities
2018-11-09
where and are the effective densities of states of electrons and holes in a two-dimensional subband, respectively; Let us assume that the equality is satisfied under optical excitation, and find the dependence of the position of the quasi Fermi levels of electrons and holes on the temperature
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Fourth the contextual features we
2018-11-09
Fourth, the contextual features we examined appear to have unique and pernicious consequences for women. While differences between states in the personal characteristics of women and men contributed to state variation in mortality to a similar degree, the contextual features explained more than twic
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The objective of this study was therefore to
2018-11-09
The objective of this study was therefore to investigate the prevalence, the effect of SES on prevalence and consequences of work-related physical assaults among people in large Japanese companies using data from the large-scale cross-sectional survey within the Japan Work Stress and Health Cohort S
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Introduction It is plausible that working at an early
2018-11-09
Introduction It is plausible that working at an early age has a strong negative impact on future individual earnings and, consequently, on national income. This hypothesis seems to be widely accepted by academics and policymakers. However, there is little empirical evidence supporting it. There is
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To calculate the intensity and duration of dengue transmissi
2018-11-09
To calculate the intensity and duration of dengue transmission, a seasonality curve was generated by plotting the decadally averaged VC as a function of month for each of the 10 cities first and then for each decade over the two centuries. The intensity of DEP was estimated by averaging the VC over
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The clinical heterogeneity in AOS patients makes
2018-11-09
The clinical heterogeneity in AOS patients makes it difficult to study SMAD3 mutational effects on aneurysm formation. Fortunately, due to the homogenous genetic background, genetically engineered mouse models are useful in pinpointing the specific molecular mechanism leading to disease. Smad3 knock
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