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Introduction It is plausible that working at an early
2018-11-09
Introduction It is plausible that working at an early age has a strong negative impact on future individual earnings and, consequently, on national income. This hypothesis seems to be widely accepted by academics and policymakers. However, there is little empirical evidence supporting it. There is
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To calculate the intensity and duration of dengue transmissi
2018-11-09
To calculate the intensity and duration of dengue transmission, a seasonality curve was generated by plotting the decadally averaged VC as a function of month for each of the 10 cities first and then for each decade over the two centuries. The intensity of DEP was estimated by averaging the VC over
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The clinical heterogeneity in AOS patients makes
2018-11-09
The clinical heterogeneity in AOS patients makes it difficult to study SMAD3 mutational effects on aneurysm formation. Fortunately, due to the homogenous genetic background, genetically engineered mouse models are useful in pinpointing the specific molecular mechanism leading to disease. Smad3 knock
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The progression of a GBM depends on invasive
2018-11-09
The progression of a GBM depends on invasive growth marked by mesenchymal cell features. It therefore remains a critical priority to expand our knowledge of how the mesenchymal features are modulated. We have employed aSICS as an integrative modeling method to identify regulators of cancer subtypes.
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Adolescent neural development of emotional
2018-11-09
Adolescent neural development of emotional attention has been initially investigated by a handful of cross-sectional studies. For negative distractors two studies suggest ongoing development of prefrontal regions: Monk et al. (2003) reported lower ACC activation in adults compared to adolescents for
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The second aim of the study was to investigate whether
2018-11-09
The second aim of the study was to investigate whether sensorimotor alpha suppression during action observation is also somatotopically-organised. We found that adults activated their sensorimotor Neuronal Signaling Library in a clear somatotopic fashion during the observation of arm and leg action
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Currently so much effort has
2018-11-09
Currently, so much effort has been devoted to study ZnO NPs as a very promising gas sensing due to its high activity, low cost and environmentally friendly feature and semiconductor properties. It is well known that gas sensors is strongly depends on the large surface-to volume ratio it provided tha
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Aunque la emigraci n de mexicanos hacia
2018-11-09
Aunque la emigración de mexicanos hacia aquel país es un fenómeno muy antiguo, el incremento acelerado que se ha experimentado en las últimas tres décadas no tiene punto de comparación con los antecedentes históricos del flujo migratorio entre ambos países. Como puede apreciarse en la gráfica 3, hub
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Estimados Lectores En sus manos tienen el n mero
2018-11-09
Estimados Lectores: En sus manos tienen el número 400 de Economía Informa, lo cual representa un motivo de orgullo y festejo para nuestra comunidad; especialmente para quienes han hecho posible su existencia y su publicación periódica durante todos estos años; me refiero no solo mct2 pathway los pr
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Nevertheless other subtype D genes
2018-11-09
Nevertheless, other subtype D genes in CRF19_cpx (gag and nef) not investigated in this study might also be associated with increased viral replication and in vivo pathogenesis. In HIV-1, Gag and Nef have been documented to contain the highest CD8 epitope density and are more frequently recognized b
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Neutrophils are one of the
2018-11-09
Neutrophils are one of the first responding immune cells to an infection. The migration of neutrophils into the site of infection–inflammation is mediated by PAMPs from microbes or DAMPs derived from disrupted host cells. At the site of infection, neutrophils rapidly combat pathogens by unleashing R
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A concern for many potential inhibitors
2018-11-09
A concern for many potential inhibitors of restenosis is that their anti-proliferative effects are not specific to SMC and can therefore also inhibit proliferation of endothelial cells (EC) that line the lumen. Delayed re-endothelialization of the treated area creates a thrombogenic surface for plat
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Our findings indicate that rat
2018-11-08
Our findings indicate that rat ESCs are more sensitive to GSK inhibition primarily because of the relative abundance of LEF1, which favors the activation of differentiation genes. Their collective expression may challenge and destabilize the self-renewal circuitry. The TOPFlash assays also suggest t
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Besides their direct effect on cartilage ASCs might act on
2018-11-08
Besides their direct effect on cartilage, ASCs might act on the other joint tissues as synovial membrane, ligaments, meniscus and subchondral bone that are also altered in OA. Although OA is not considered an inflammatory disease, pro-inflammatory cytokines, namely IL-1β and TNF-α, are secreted by O
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Taken together we conclude that Lats may regulate adult card
2018-11-08
Taken together, we conclude that Lats may regulate adult cardiomyocyte hypertrophy independent of Yap or Tead1. Rather than controlling cardiac hypertrophic growth, the canonical Hippo/Yap pathway is crucial for regulation of cardiomyocyte survival in the adult heart. This parallels the findings in
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