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Simon discusses this in the remarks and historical
2020-02-22
Simon discusses this in the remarks and historical notes section following the general discussion of dynamically defined Verblunsky coefficients; see [12, pp. 706–707]. He points out that “understanding almost periodic Verblunsky coefficients is an intriguing open area” and in particular describes w
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To simulate the inhibition of the
2020-02-22
To simulate the inhibition of the enzyme by organophosphorus, carbamate insecticides or nerve agents, a reversible cholinesterase inhibitor physostigmine was used for most experiments for safety reasons. However, the results of the measurements were verified using the soman organophosphate, which is
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Carboplatin Previous studies demonstrated that cPLA
2020-02-22
Previous studies demonstrated that cPLA2α translocates to the phagosomal membrane during macrophage phagocytosis through mechanisms that, in humans, involve phosphorylation of the enzyme by c-Jun N-terminal kinases and membrane association via the cationic cluster of four lysine residues present at
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From these and other studies it is clear that
2020-02-22
From these and other studies, it is clear that acriflavine is an interesting capmatinib receptor with pleiotropic anticancer effects [21], [22], [43]. Its past systemic use in the clinical setting as an antibiotic without any major toxicity reported encourages further development of the drug for ca
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A-740003 WES and validation by Sanger sequencing
2020-02-22
WES and validation by Sanger sequencing in PNGS-252 revealed an apparent homozygous c.4C>G missense alteration (GenBank: NM_014176.3), resulting in the amino A-740003 substitution p.Gln2Glu (Figure 1A). This mutation must be very rare, because this is not listed in the NHLBI Exome Sequencing Projec
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DUBs are involved in cell cycle regulation and
2020-02-22
DUBs are involved in 487 regulation and DNA damage pathways and since, in cancer and different stress conditions all the proteins which regulate cell cycle and DNA damage/repair are either up/down regulated (Singh et al., 2013, Singh et al., 2011, Kumar and de Massy, 2010, Gupta et al., 2010), it wo
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ATP dependent DNA ligases in
2020-02-22
ATP-dependent DNA ligases in vertebrates are divided in three families [7]. Family I DNA ligases are responsible for sealing the nicks during DNA replication and in long-patch base excision repair (BER). Family III DNA ligases are involved in short-patch BER. Lastly, family IV DNA ligases are involv
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mitotane Increased levels of PCNA monoubiquitination by UbL
2020-02-21
Increased levels of PCNA monoubiquitination by UbL73P expression in a damage-independent manner mimics the phenotype observed for USP1 knockdown (Huang et al., 2006, Jones et al., 2012). USP1 is the only DUB to date shown to remove ubiquitin from PCNA in vivo. This finding reveals the highly dynamic
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br Introduction Localized degenerative and progressive enlar
2020-02-21
Introduction Localized, degenerative and progressive enlargement of the aortic diameter involves all layers of the vessel wall may ultimately rupture creating a catastrophic cardiovascular event [1,2]. An aneurysm may be located in the thoracic or abdominal aortic wall with different clinical app
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br Discussion Our data demonstrate that the bicyclam AMD
2020-02-21
Discussion Our data demonstrate that the bicyclam AMD3100 strongly interacts with CXCR-4, whereas DS and AR177, two other compounds that also interfere with virus entry into the gdc-0980 synthesis (and interfere with virus binding), do not. AMD3100 is a unique compound in that it interferes with
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In summary our findings indicate that bFGF stimulates
2020-02-21
In summary, our findings indicate that bFGF stimulates CPT1 expression, FA oxidation and lactate production with the participation of PPARβ/δ activation. On the other hand, this investigation shows that FSH concomitantly regulates the expression of genes involved in FA metabolism and in mitochondria
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To determine the time course of ZD P
2020-02-21
To determine the time course of ZD2767P+CPG2 DNA–DNA interstrand cross-link formation, HT29 and LS174T colorectal tumour DL-Menthol were exposed to the drug for 10, 30 or 60 min. The levels of DNA interstrand cross-links in HT29 or LS174T cells did not increase with exposure time, suggesting that Z
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br Materials and methods br Results br Discussion The nitric
2020-02-21
Materials and methods Results Discussion The nitric oxide generating enzymes of the NOS family comprise three isoforms: nNOS, iNOS and eNOS [31]. Expression of eNOS is mainly found in endothelial Misoprostol where it physically promotes vasodilation [32]. Conversely, evidence also indicate
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In conclusion our results provide a new mechanistic insight
2020-02-21
In conclusion, our results provide a new mechanistic insight into the signaling pathways mediating TDCIPP-induced apoptosis in cultured neuronal cells. We showed that TDCIPP-induced neuronal cell cytotoxicity and death are mediated via the ER stress-regulated apoptotic pathway, wherein the induction
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Similar to EGFR another receptor tyrosine kinase RTK fibrobl
2020-02-21
Similar to EGFR, another receptor tyrosine kinase (RTK), fibroblast growth factor receptor 4 (FGFR4), is gaining attention in the lung cancer setting. The protein expression of this receptor has been recently associated with a negative impact on lung cancer prognosis, supporting the idea that FGFR4
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