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Quantifying diffusion is greatly complicated by the ubiquito
2020-07-27
Quantifying cpmt synthesis is greatly complicated by the ubiquitous unevenness of soil surfaces and related water films, which introduce a large uncertainty into size (area) and quality of contact between the soil surface and the membrane, the problem being particularly substantial in well aggregat
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We demonstrated that the specific role of USP in
2020-07-27
We demonstrated that the specific role of USP22 in enhancing EGFR recycling back to the plasma membrane. USP22 might interact directly with the components of ESCRTs (endosomal sorting complexes required for transports), such as STAM2 and Eps15, as has been shown for other DUBs [32,[37], [38], [39]].
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gaba receptor Introduction Cognitive impairment is a core st
2020-07-27
Introduction Cognitive impairment is a core, stable feature of schizophrenia that limits patient functioning and well-being (Keefe and Harvey, 2012) and associates with poor functional outcome (Fervaha et al., 2014, Kontaxaki et al., 2014). Studies also indicate that cognitive deficits occur prior
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br Dihydroorotate dehydrogenase DHODH is an enzyme essential
2020-07-27
Dihydroorotate dehydrogenase (DHODH) is an enzyme essential to pyrimidine de novo biosynthesis. It catalyzes oxidative conversion of dihydroorotate to orotate using the co-factors flavin mononucleotide (FMN) and ubiquinone (CoQ) in the redox process. Since blocking pyrimidine biosynthesis has an a
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The discoidin domain receptors DDR and
2020-07-27
The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases that are activated by different types of collagen (Shrivastava et al., 1997, Vogel et al., 1997). Both receptors interact with a number of fibrillar collagens, and DDR1, but not DDR2, is also activated by the network-formin
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It has been shown that DAPK
2020-07-27
It has been shown that DAPK promotes the cytoplasmic retention of ERK, thereby inhibiting ERK signaling in the nucleus. In addition, when DAPK-1 mutation alters the oligomeric structure of the death domain, de-stabilizes DAPK-1 binding to ERK, and prevents ERK:DAPK-1-dependent apoptosis [47]. Howeve
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Patients with a tumor of cm or
2020-07-27
Patients with a tumor of 4 cm or greater were more likely to have lymph node or tumor metastasis (Fisher’s test p = 0.0001 and 0.0003, respectively). In this smaller patient group a significant correlation between higher DAPK-1 mRNA ro bio 2 mg in tumor and normal tissue in tumor-free patients comp
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Interestingly resveratrol protects from alcohol
2020-07-27
Interestingly, resveratrol protects from alcohol-induced fatty liver disease in part by increasing fatty [Ala92]-p16 (84-103) oxidation as observed through greater B-OHB coupled with enhanced adiponectin, and increased expression of Cpt1a as well as other genes associated fatty acid oxidation [70,7
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DP was the first PGD receptor discovered It
2020-07-27
DP was the first PGD receptor discovered. It belongs to the prostanoid receptor family of GPCRs and is expressed on airway epithelium, smooth muscle and platelets. Upon stimulation, DP activates adenylate cyclase and increases the level of cAMP primarily via Gs-dependent pathways. Genetic analysis o
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Next we examined the SAR of
2020-07-27
Next, we examined the SAR of the amide linker moiety of 15-19 and 15-20 (Table 3). An N-methylamide 15-34, which was devoid of the hydrogen bond donor (NH) showed a 15-fold reduction in the binding affinity (15-34: IC50=210nM), suggesting that the hydrogen bond donor (NH) is likely to contribute to
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In this study we examined the role of a well
2020-07-27
In this study we examined the role of a well characterized genetic polymorphism in the COMT gene in mediating cognitive antipsychotic treatment effects in first episode psychosis (FEP). We considered catechol-O-methyltransferase (COMT) to be a potentially important baseline consideration in a pharma
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Although Hyp incorporation increased with NaCl addition the
2020-07-27
Although Hyp incorporation increased with NaCl addition, the overall yields of protein decreased with increasing NaCl concentrations (Fig. 2). Reasonable yields were obtained for additions up to 200 mM NaCl, but at higher concentrations a major loss in yield was seen (Fig. 2). At 700 mM and 800 mM N
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br Results The AR genotype frequencies are
2020-07-26
Results The AR genotype frequencies are shown in Table 1. Alleles at the two loci are in linkage disequilibrium, as expected for such closely linked loci and consistent with previous findings (Kittles et al., 2001). The genotype frequency for the DBH 1021 polymorphism is similar to previous find
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Compounds and were synthesized according to Reductive aminat
2020-07-25
Compounds and () were synthesized according to . Reductive amination of ethyl acetoacetate with aniline afforded ester . Saponification of followed by intramolecular Friedel–Crafts acylation afforded ketone . Amide formation with benzoyl chloride followed by a reductive amination yielded compound .
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Carnitine acetyltransferase CrAT transesterifies short chain
2020-07-25
Carnitine acetyltransferase (CrAT) transesterifies short-chain acyl-CoAs, and is located both in mitochondria and peroxisomes. In yeasts and mammals this protein is the product of a single gene [20,21] and the sorting to different organelles is evolutionary conserved, although the mechanism of diffe
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