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Ubiquitin C terminal hydrolase L UCTL is
2020-07-31
Ubiquitin C-terminal hydrolase-L1 (UCTL1), is one of the most explored DUBs which is involved in neurodegenerative disorders such as Parkinson disease. It has been shown that expression of neurons of neuroendocrine system and gonads is unregulated in non-small cell lung cancer (Hibi et al., 1998, Hi
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Introduction Since the recognition of AIDS in more than
2020-07-30
Introduction Since the recognition of AIDS in 1981 more than thirty-five years ago, nearly 70 million individuals have been infected with human immunodeficiency virus type 1 (HIV) and roughly half have died (http://www.unaids.org/en/resources/documents/2016/AIDS-by-the-numbers). Although the introd
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We demonstrated that the specific role of
2020-07-29
We demonstrated that the specific role of USP22 in enhancing EGFR recycling back to the plasma membrane. USP22 might interact directly with the components of ESCRTs (endosomal sorting complexes required for transports), such as STAM2 and Eps15, as has been shown for other DUBs [32,[37], [38], [39]].
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Unwinding of dsDNA by RecBCD involves an intimate
2020-07-29
Unwinding of dsDNA by RecBCD involves an intimate coordination between subunits, and is proposed to occur in several sequential steps, utilizing a quantum inchworm mechanism. First, the enzyme binds to dsDNA ends with the leading domain of RecB reaching out 23 nt ahead of the ssDNA/dsDNA junction. H
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According to the docking study
2020-07-29
According to the docking study results, the difference in biological activity of the tested compounds despite of their similar chemical structure could be explained. For the active molecules like 26, the presence of aromatic substituent with its conformational freedom seems to be crucial for the int
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In summary our findings show that
2020-07-29
In summary, our findings show that LPS can activate CysLT2R on microglial latrunculin to induce microglial inflammation and microglia-dependent neuronal death. Furthermore, pharmacological inhibition or knocking down of CysLT2R expression protects neurons against neurotoxicity via suppression of LP
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br Conclusions br Funding br Introduction
2020-07-29
Conclusions Funding Introduction One major challenge in the chemistry and physics of actinide and lanthanide (f-ion) complexes is the understanding of the role that f-electrons play in the magnetism in general and in the exchange coupling in particular. This is in marked STF 083010 to tran
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Classically the D R family activates the G s
2020-07-28
Classically, the D1R family activates the Gαs/olf family of G proteins, leading to activation of adenylyl cyclase (AC) and increased cAMP production, whereas the D2R class recruits Gαi/o signaling to inhibit AC and cAMP production (Beaulieu and Gainetdinov, 2011). In striatal spiny projection neuron
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The human serotonin hydroxytryptamine HT receptor family con
2020-07-28
The human serotonin (5-hydroxytryptamine; 5-HT) receptor family consists of 14 receptor subtypes to date, which are primarily G protein-coupled receptors (GPCRs) with 5-HT3 being the sole ligand-gated ion channel (Alexander et al., 2017). These receptors are widely distributed in the central and per
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The reduced DNA stability at RH
2020-07-28
The reduced DNA stability at 100% RH confirms previous results for incubates at these conditions, although in the present study amplifiable DNA still survived for months. The crucial point appears to be the onset of microbial growth, which happened at room temperature and at 35 °C. In the biological
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The following are the supplementary data related to
2020-07-28
The following are the supplementary data related to this article. Introduction Hand, foot, and mouth disease (HFMD) is a common childhood infectious disease that has overwhelmed the Asia-Pacific region in recent years (Xing et al., 2014, Puenpa et al., 2018, Anh et al., 2018, Fujimoto et al., 20
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Its auto inhibited structure contain N terminus packed
2020-07-28
Its auto-inhibited structure contain N-terminus packed between residues of the glycine-rich loop, the activation loop and the αC helix. Both its N and C termini wrapping around the αC helix and the JM domain adopts a twisted hairpin conformation (Fig. 2.1B). The exclusive and unphosphorylated tyrosi
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In the proposed language a concrete architectural
2020-07-28
In the proposed language, a concrete architectural model consists of a set of individual components (ConcreteComponent) and a set of relationships (Relationship) among them. Each component has a type, defined by ComponentType. The container component type identifies a component that contains other c
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As far as we know there is no study
2020-07-28
As far as we know, there is no study directly investigating the effect of the COMT Val158Met polymorphism on well-being, which is related to, but much more complex than, say, affective processing. Moreover, although a few previous studies demonstrated the involvement of serotoninergic CK 666 in wel
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Recent studies have shown that some
2020-07-28
Recent studies have shown that some CLC genes participate in plant salt tolerance and have speculated that they function by mediating Cl− transport across the tonoplast. For instance, AtCLCc, a vacuolar anion transporter, is shown to be involved in the regulation of stomatal movement and to contrib
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