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Long term exposure to toxic
2018-10-29
Long-term exposure to toxic agents, including various types of herbal medicine and Chinese medicine, may be related to idiopathic mesenteric phlebosclerosis. Diseases previously reported to be associated with idiopathic mesenteric phlebosclerosis include hypertension, cerebral vascular accident, chr
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Furthermore Kobayashi et al reported that the incidence of
2018-10-29
Furthermore, Kobayashi et al reported that the incidence of gallstones was significantly higher after total gastrectomy than after partial gastrectomy; our study presented similar findings (40% vs. 17.8%; odds ratio, 3.8). Furthermore, an increased incidence of acute cholecystitis was observed in pa
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NO is synthesized from L arginine by the
2018-10-29
NO is synthesized from L-arginine by the NOS family of enzymes. Two NOS isoforms were previously identified: constitutive NOS and iNOS. Constitutive NOS comprises endothelial NOS (eNOS) and neuronal NOS. NO plays a crucial role in the homeostasis of hepatic circulation under physiological conditions
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br Regulation of Nrf activation The
2018-10-29
Regulation of Nrf2 activation The core of the Nrf2 regulation is Keap1. Keap1 functions as a negative regulator of Nrf2 by promoting ubiquitination and proteasomal degradation of Nrf2 [15]. Since Keap1 has highly reactive sulfhydryl groups in its cysteine residues, it is considered as a sensor f
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These results showed that the phenolic extracts
2018-10-29
These results showed that the phenolic extracts scavenged the radicals and prevented the oxidation of the membrane lipids and DCFH, thereby reducing the formation of DCF. DCF is formed from the reaction between DCFH trapped in the thymidylate synthase inhibitors and the ABAP-induced peroxyl radicals
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Fgfs activating only FGFRb isotypes had no effect on
2018-10-29
Fgfs activating only FGFRb isotypes had no effect on the number of EpCAM+Sox17-GFPHi EAI045 developing in response to activin or on the number of EdU-incorporating cells. Since FGFR inhibitors reduce the numbers of Sox17-GFPHi cells (Hansson et al., 2009) we suspect that endogenous Fgf signaling is
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Introduction Human embryonic stem cells hESCs which
2018-10-29
Introduction Human embryonic stem cells (hESCs), which are derived from the inner cell mass of blastocysts, exhibit unique features including pluripotency, self-renewal and the capacity to differentiate into three germ layers both in vitro and in vivo (Thomson et al., 1998). Several previous studi
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Bmi is known to act in a concentration dependent manner
2018-10-29
Bmi1 is known to act in a concentration-dependent manner to control a delicate balance between self-renewal and differentiation (Cui et al., 2006). We found that Bmi1 expression is highest during intermediate stages of BTIC differentiation, when CD133+ progenitors transition to CD133− cells prior to
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To establish precisely the relationships between cell lineag
2018-10-29
To establish precisely the relationships between cell lineages, cell identity must be defined at the branching point of these two hematopoietic lineages, and individual cells that are free of the influence of environmental signals should be analyzed. In the adult hematopoietic system, various diffe
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br Patients and methods br
2018-10-26
Patients and methods Introduction Embryonic stem (ES) BYL-719 Supplier can give rise, in vivo, to the ectodermal, endodermal, and mesodermal germ layers and, in vitro, can differentiate into multiple cell lineages (Reubinoff et al., 2000; Wobus and Boheler, 2005). This ability to form differen
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Among the potential stem cell candidates
2018-10-26
Among the potential stem cell candidates for therapeutic development, we have highlighted the existence of a promising multipotent contender residing within the nasal olfactory mucosa (Delorme et al., 2010; Murrell et al., 2005; Tome et al., 2009), a peripheral and permanently self-renewing nervous
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On the other hand a major advantage
2018-10-26
On the other hand, a major advantage of this alternative double-reporter genetic model is to provide a clear-cut qualitative answer as to whether new CMs are formed after injury and if so, whether these new CMs originated predominantly from pre-existing CMs or from another cell population. If no new
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DNA methylation can be passively lost during DNA replication
2018-10-26
DNA methylation can be passively lost during DNA replication if it is not maintained by DNA methyltransferases (Chen and Riggs, 2011; Li and Zhang, 2014; Moore et al., 2013; Ooi et al., 2009). Besides passive loss due to DNA replication during cell divisions, DNA methylation can also be subject to a
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aniracetam All iPSC derived neurons demonstrated expression
2018-10-26
All iPSC-derived neurons demonstrated expression of functional neurotransmitter receptors, responding to glutamate/glycine, GABA and to a lower extend to acetylcholine. Interestingly, the neuronal cultures also developed synchronized spontaneous calcium oscillations, which were likely to reflect ani
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Small or immature teratomas are
2018-10-26
Small or immature teratomas are particularly hard to detect due to the lack of tissues with high secretion levels such as gland-like structures. In line with that, we found one teratoma in our test set for which none of the eight tested biomarkers was positive. Histological characterization showed t
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